Idebenone, a mitochondrial electron transport chain regulator with antioxidant properties, has been used to treat mitochondrial diseases by reducing ROS levels and improving mitochondrial function [521]
were often deficient in nutrients
53,54 However, it has also been suggested that the enhanced release of proinflammatory cytokines (TNF-, IL-1, IL-6, and IL-10) and chemokines (monocyte chemoattractant protein-1, macrophage inflammatory protein-2, and IL-8) further promotes hepatocyte damage, thereby aggravating necrosis
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